Insertion of a novel DNA sequence, IS <i>1186</i>, upstream of the silent carbapenemase gene <i>cfiA</i>, promotes expression of carbapenem resistance in clinical isolates of <i>Bacteroides fragilis</i>

Abstract excerpt

A small number of isolates of Bacteroides fragilis, an anaerobic pathogen of the human intestinal flora, carries a copy (or copies) of the carbapenemresistance gene, cfiA, which may be silent or expressed. We have studied the mechanism of activation of the frequently silent gene in in vitro-selected mutants and in clinical isolates. In both types of strains, activation was observed as the consequence of the...

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