Article
Regulation of YKL-40 expression during genotoxic or microenvironmental stress in human glioblastoma cells.
Cancer science - 1 Mar 2005
Junker Nanna, Johansen Julia S, Hansen Lasse T, Lund Eva L, Kristjansen Paul E G
Abstract excerpt
YKL-40 is a 40 kDa secreted glycoprotein belonging to the family of 'mammalian chitinase-like proteins', but without chitinase activity. YKL-40 has a proliferative effect on fibroblasts, chondrocytes and synoviocytes, and chemotactic effect on endothelium and vascular smooth muscle cells. Elevated YKL-40 levels are found in serum of patients with diseases characterized by inflammation, fibrosis and tissue...
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