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The different role of YKL-40 in glioblastoma is a function of MGMT promoter methylation status

20 Aug 2020

Abstract excerpt

-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a significant prognostic marker for Temozolomide (TMZ) resistance in GBM patients. YKL-40 is a molecular marker for the mesenchymal subtype of GBMs and is responsible for TMZ resistance. However, underlying mechanisms by which MGMT epigenetics impacts patient outcomes and the function of YKL-40 are not fully determined. Herein, we performed in...

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PMID: 32820151
DOI: 10.1038/s41419-020-02909-9

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