Article
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues.
Bioorganic & medicinal chemistry letters - 3 Sept 2001
Ludovici D W, De Corte B L, Kukla M J, Ye H, Ho C Y, Lichtenstein M A, Kavash R W, Andries K, de Béthune M P, Azijn H, Pauwels R, Lewi P J, Heeres J, Koymans L M, de Jonge M R, Van Aken K J, Daeyaert F F, Das K, Arnold E, Janssen P A
Abstract excerpt
The synthesis and anti-HIV-1 activity of a series of diarylpyrimidines (DAPYs) are described. Several members of this novel class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) are extremely potent against both wild-type and a panel of clinically significant single- and double-mutant strains of HIV-1.
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