Article
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.
Cell - 30 Dec 1994
Baynash A G, Hosoda K, Giaid A, Richardson J A, Emoto N, Hammer R E, Yanagisawa M
Abstract excerpt
Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon and pigmentary disorders in mice and humans. We report that a targeted disruption of the mouse endothelin-3 ligand (EDN3) gene produces a similar recessive phenotype of megacolon and coat color spotting. A natural recessive mutation that results in the same developmental defects in mice, lethal spotting (ls), failed to complement...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Endothelins
- Female
- Hair Color
- Hirschsprung Disease
- Homozygote
- Male
- Mice
- Mice, Knockout
- Mice, Mutant Strains