Article
Genetic analysis of the GABRA1 gene in patients with essential tremor.
Neuroscience letters - 19 Jun 2006
Deng Hao, Xie Wen-Jie, Le Wei-Dong, Huang Mao-Sheng, Jankovic Joseph
Abstract excerpt
The gamma-aminobutyric acid A (GABA-A) receptor mediates inhibitory neurotransmission in the brain and as such may be involved in certain neurological movement disorders, such as tremor. GABA-A receptor alpha 1 (Gabra)(-/-) mice have been reported to exhibit postural and kinetic, alcohol-responsive, tremor that is characteristic of essential tremor (ET), the most common form of tremor. To determine whether ET is...
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