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Article

Cadmium down-regulates human OGG1 through suppression of Sp1 activity.

The Journal of biological chemistry - 1 Jul 2005

Youn Cha-Kyung, Kim Soo-Hyun, Lee Do Young, Song Seung Hee, Chang In-Youb, Hyun Jin-Won, Chung Myung-Hee, You Ho Jin

Abstract excerpt

Cadmium is a well known human and animal carcinogen and is a ubiquitous contaminant in the environment. Although the carcinogenic mechanism of cadmium is a multifactorial process, oxidative DNA damage is believed to be of prime importance. In particular, cadmium suppresses the capacity of cells to repair oxidative DNA damage. In this study, cadmium treatment led to a significant increase in gamma-ray-induced...

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Source

Identifiers

PMID: 15760895
DOI: 10.1074/jbc.M412793200

Genes

OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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