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Article

Decreased selenium-binding protein 1 in esophageal adenocarcinoma results from posttranscriptional and epigenetic regulation and affects chemosensitivity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2010

Silvers Amy L, Lin Lin, Bass Adam J, Chen Guoan, Wang Zhuwen, Thomas Dafydd G, Lin Jules, Giordano Thomas J, Orringer Mark B, Beer David G, Chang Andrew C

Abstract excerpt

PURPOSE: The chemopreventive effects of selenium have been extensively examined, but its role in cancer development or as a chemotherapeutic agent has only recently been explored. Because selenium-binding protein 1 (SELENBP1, SBP1, hSP56) has been shown to bind selenium covalently and selenium deficiency has been associated with esophageal adenocarcinoma (EAC), we examined its role in EAC development and its...

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Source

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Identifiers

PMID: 20332323
DOI: 10.1158/1078-0432.CCR-09-2801
PMCID: PMC2953959

Genes

SELENBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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