Article
Improving functional annotation of non-synonomous SNPs with information theory.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2005
Karchin R, Kelly L, Sali A
Abstract excerpt
Automated functional annotation of nsSNPs requires that amino-acid residue changes are represented by a set of descriptive features, such as evolutionary conservation, side-chain volume change, effect on ligand-binding, and residue structural rigidity. Identifying the most informative combinations of features is critical to the success of a computational prediction method. We rank 32 features according to their...
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