Better prediction of functional effects for sequence variants.

doi:10.1186/1471-2164-16-S8-S1

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Article

Better prediction of functional effects for sequence variants.

BMC genomics - 1 Jan 2015

Hecht Maximilian, Bromberg Yana, Rost Burkhard

Abstract excerpt

Elucidating the effects of naturally occurring genetic variation is one of the major challenges for personalized health and personalized medicine. Here, we introduce SNAP2, a novel neural network based classifier that improves over the state-of-the-art in distinguishing between effect and neutral variants. Our method's improved performance results from screening many potentially relevant protein features and from...

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Identifiers

PMID: 26110438
DOI: 10.1186/1471-2164-16-S8-S1
PMCID: PMC4480835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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