Article
[Correlation of matrix metalloproteinase-3 polymorphism to genetic susceptibility and lymph node metastasis of non-small cell lung cancer].
Ai zheng = Aizheng = Chinese journal of cancer - 1 Mar 2005
Fang Shu-Mei, Jin Xia, Li Yan, Wang Rui, Guo Wei, Wang Na, Zhang Jian-Hui
Abstract excerpt
BACKGROUND & OBJECTIVE: Matrix metalloproteinases (MMPs) might be involved in invasion and metastasis of tumors by degrading extracellular matrix (ECM) and basement membrane (BM). The 5A or 6A single nucleotide polymorphism (SNP) at the -1 171 bp site of promoter region of MMP-3 may modify the transcription and local expression of MMP-3. This study was to investigate correlation of the MMP-3 SNP with genetic...
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