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Article

Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2005

Hu Zhibin, Huo Xiang, Lu Daru, Qian Ji, Zhou Jiannong, Chen Yijiang, Xu Lin, Ma Hongxia, Zhu Jingfu, Wei Qingyi, Shen Hongbing

Abstract excerpt

PURPOSE: Matrix metalloproteinase 9 (MMP-9) plays critical roles in cancer development and aggression. Nonsynonymous single-nucleotide polymorphisms (SNP) in the functional domain of the MMP-9 gene may influence substrate and inhibitor binding and contribute to cancer predisposition and aggression. PATIENTS AND METHODS: To test our hypothesis that common nonsynonymous SNPs, R279Q, P574R, and R668Q, in MMP-9 are...

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PMID: 16061858
DOI: 10.1158/1078-0432.CCR-05-0311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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