Article
The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria.
British journal of clinical pharmacology - 1 Mar 2005
Hombhanje F W, Hwaihwanje I, Tsukahara T, Saruwatari J, Nakagawa M, Osawa H, Paniu M M, Takahashi N, Lum J K, Aumora B, Masta A, Sapuri M, Kobayakawa T, Kaneko A, Ishizaki T
Abstract excerpt
AIMS: We assessed the disposition of oral amodiaquine (AQ) and CYP2C8 polymorphism in 20 children with falciparum malaria. METHODS: AQ and DEAQ concentrations were determined with SPE-HPLC method. CYP2C8 genotypes were assessed by PCR-RFLP method. RESULTS: AQ was not detectable beyond day 3 postdose. Cmax for DEAQ was reached in 3.0 days. The mean values for t1/2, MRT, and AUCtotal were 10.1 days, 15.5 days and...
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