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Changes in Mitochondrial Rna Production in Cells Treated with Nucleoside Analogues

1 Jan 2005

Abstract excerpt

BACKGROUND: To investigate mitochondrial (mt) toxicity of antiretroviral drugs further, we developed a novel real-time PCR-based assay for the quantification of mtRNA. We analysed the effects of stavudine (d4T), didanosine (ddl) and zidovudine (AZT) on the production of mtRNAs in different human cell lines and compared the production with the amount of mtDNA present in the same cells. MATERIALS AND METHODS:...

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PMID: 15751778
DOI: 10.1177/135965350501000112

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