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Article

Quantitation of Blood Lymphocyte Mitochondrial DNA for the Monitoring of Antiretroviral Drug–Induced Mitochondrial DNA Depletion

1 Aug 2003

Abstract excerpt

OBJECTIVE: To investigate the impact of antiretroviral treatment on the mitochondrial DNA (mtDNA) content of peripheral blood mononuclear cells (PBMCs) from HIV-1-infected patients. DESIGN: As absolute mtDNA copy numbers widely differ between individuals, we performed a longitudinal analysis where the patient's first historical specimen was obtained as a baseline reference for relative comparison with subsequent...

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PMID: 12869834
DOI: 10.1097/00126334-200308010-00006

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