Article
Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling.
Cerebral cortex (New York, N.Y. : 1991) - 1 Apr 2005
Spires Tara L, Molnár Zoltán, Kind Peter C, Cordery Patricia M, Upton A Louise, Blakemore Colin, Hannan Anthony J
Abstract excerpt
The phospholipase C-beta1 (PLC-beta1) signalling pathway, activated via metabotropic glutamate receptors (mGluRs), is implicated in activity-dependent development of the cerebral cortex, as both PLC-beta1 and mGluR5 knockout mice exhibit disrupted barrel formation in somatosensory cortex. To characterize the effects of this signalling system on development of synaptic circuitry in barrel cortex, we have examined...
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