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Article

Evolutionary game theory in an agent-based brain tumor model: exploring the 'Genotype-Phenotype' link.

Journal of theoretical biology - 7 Jan 2006

Mansury Yuri, Diggory Mark, Deisboeck Thomas S

Abstract excerpt

To investigate the genotype-phenotype link in a polyclonal cancer cell population, here we introduce evolutionary game theory into our previously developed agent-based brain tumor model. We model the heterogeneous cell population as a mixture of two distinct genotypes: the more proliferative Type A and the more migratory Type B. Our agent-based simulations reveal a phase transition in the tumor's velocity of...

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Source

Identifiers

PMID: 16081108
DOI: 10.1016/j.jtbi.2005.05.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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