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Article

Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells.

Somatic cell and molecular genetics - 1 Mar 1992

Hayashi J, Takemitsu M, Nonaka I

Abstract excerpt

The role of mitochondrial DNA (mtDNA) in the expression of the transformed phenotype was examined using mtDNA-less HeLa cells. Complete depletion of mtDNA and its products in the mtDNA-less HeLa cell line, EB8, was confirmed by Southern blot analysis and by [35S]methionine labeling of mitochondrially synthesized polypeptides. The tumorigenicity of the EB8 cells was assayed by inoculation of 1 x 10(7) cells...

Topics

Animals
Blotting, Southern
Carcinogenicity Tests
Cell Division
Cell Fusion
Cell Transformation, Neoplastic
DNA, Mitochondrial
Gene Expression Regulation, Neoplastic
HeLa Cells
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Microscopy, Electron

Mutation

Neoplasm Transplantation

Source

Identifiers

PMID: 1574738
DOI: 10.1007/BF01233159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1574738-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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