Article
Paragangliomas in patients with mutations of the SDHD gene.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Mar 2005
Boedeker Carsten Christof, Neumann Hartmut P H, Ridder Gerd Jürgen, Maier Wolfgang, Schipper Jörg
Abstract excerpt
OBJECTIVE: Paragangliomas represent neoplasms of neural crest origin that arise from paraganglia. Mutations in the gene encoding succinate dehydrogenase subunit D (SDHD) are responsible for a percentage of hereditary paragangliomas. We previously described a group of 271 pheochromocytoma patients, 11 of whom had mutations of the SDHD gene. The objective of this study was to find out whether those 11 patients had...
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