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Article

Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report.

Head & neck - 1 Jul 2008

Papaspyrou Konstantinos, Rossmann Heidi, Fottner Christian, Weber Matthias M, Mann Wolf, Lackner Karl J, Helling Kai

Abstract excerpt

BACKGROUND: Paragangliomas of the head and neck are rare, mostly benign tumors. Approximately 10% to 15% of paragangliomas are caused by mutations in the succinate dehydrogenase (SDH) genes B, C, or D. These are often multifocal as part of paraganglioma syndromes and hormone secreting, and malignant particularly associated with mutations in SDHB. METHODS AND RESULTS: A 29-year-old man was seen with recurrent...

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Source

Identifiers

PMID: 18213727
DOI: 10.1002/hed.20746

Genes

SDHD
SDHB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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