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Article

Direct hepatic fate specification from mouse embryonic stem cells†

2 Mar 2005

Abstract excerpt

The molecules responsible for hepatic differentiation from embryonic stem (ES) cells have yet to be elucidated. Here we have identified growth factors that allow direct hepatic fate-specification from ES cells by using simple adherent monolayer culture conditions. ES cell-derived hepatocytes showed liver-specific characteristics, including several metabolic activities, suggesting that ES cells can differentiate...

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PMID: 15742390
DOI: 10.1002/hep.20629

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