Article
The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Oct 2008
Vimaleswaran Karani Santhanakrishnan, Luan Jian'an, Andersen Gitte, Muller Y Li, Wheeler Eleanor, Brito Ema C, O'Rahilly Stephen, Pedersen Oluf, Baier Leslie J, Knowler William C, Barroso Inês, Wareham Nicholas J, Loos Ruth J F, Franks Paul W
Abstract excerpt
The protein encoded by the PPARGC1A gene is expressed at high levels in metabolically active tissues and is involved in the control of oxidative stress via reactive oxygen species detoxification. Several recent reports suggest that the PPARGC1A Gly482Ser (rs8192678) missense polymorphism may relate inversely with blood pressure. We used conventional meta-analysis methods to assess the association between...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.