Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.

Oncogene - 28 Apr 2005

Oka Masahiro, Meacham Amy M, Hamazaki Takashi, Rodić Nemanja, Chang Lung-Ji, Terada Naohiro

Abstract excerpt

The deoxycytidine analog 5-aza-2'-deoxycitidine (5-aza-dC) is a potent chemotherapeutic agent effective against selective types of cancer. The molecular mechanism by which 5-aza-dC induces cancer cell death, however, is not fully understood. It has been accepted that the mechanism of toxicity is due to the covalent binding between the DNA methyltransferase (Dnmt) and 5-aza-dC-substituted DNA. In order to define...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azacitidine
Share to Decitabine
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to DNA Methyltransferase 3A

Share to DNA Methyltransferase 3B

Share to DNA Modification Methylases

Share to Lentivirus

Source

Identifiers

PMID: 15735669
DOI: 10.1038/sj.onc.1208540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.PMID 15735669Read ↗

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.Semantic proximity Read ↗

5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.Semantic proximity Read ↗

Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineriesSemantic proximity Read ↗

5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal.Semantic proximity Read ↗

Mechanisms of resistance to 5-aza-2′-deoxycytidine in human cancer cell linesSemantic proximity Read ↗

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation settingSemantic proximity Read ↗

De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.Semantic proximity Read ↗

5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.Semantic proximity Read ↗

Analysis of an Active Deformylation Mechanism of 5‐Formyl‐deoxycytidine (fdC) in Stem CellsSemantic proximity Read ↗

Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype.Semantic proximity Read ↗

Azacitidine and decitabine have different mechanisms of action in non-small cell lung cancer cell linesSemantic proximity Read ↗

5-Aza-2′-deoxycytidine Activates the p53/p21Waf1/Cip1 Pathway to Inhibit Cell ProliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.