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Article

Estrogen therapy fails to alter amyloid deposition in the PDAPP model of Alzheimer's disease.

Endocrinology - 1 Jun 2005

Green Pattie S, Bales Kelly, Paul Steven, Bu Guojun

Abstract excerpt

Epidemiological studies implicate estrogen deprivation as a risk factor for Alzheimer's disease and postmenopausal estrogen replacement as protective factor. One potential mechanism involves estrogen attenuation of beta-amyloid (Abeta) peptide accumulation. We examined the effect of estrogen on amyloid accumulation in female PDAPP mice, which express human amyloid precursor protein (APP) with the V717F mutation....

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Source

Identifiers

PMID: 15731362
DOI: 10.1210/en.2004-1433

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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