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Article

Integrase inhibitors in the treatment of HIV-1 infection

18 Sept 2010

Abstract excerpt

Agents active against HIV type 1 (HIV-1) that target the viral integrase by inhibiting the strand transfer step of integration have now entered the clinical arena. Raltegravir is the first in this new class. Clinical trials in treatment-experienced and in treatment-naive patients have shown that raltegravir-containing regimens have potent antiretroviral activity and are well tolerated. Drug resistance emerges...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20852268
DOI: 10.1093/jac/dkq350

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