New Transposon Tn <i>6133</i> in Methicillin-Resistant Staphylococcus aureus ST398 Contains <i>vga</i> (E), a Novel Streptogramin A, Pleuromutilin, and Lincosamide Resistance Gene

Abstract excerpt

A novel streptogramin A, pleuromutilin, and lincosamide resistance determinant, Vga(E), was identified in porcine methicillin-resistant Staphylococcus aureus (MRSA) ST398. The vga(E) gene encoded a 524-amino-acid protein belonging to the ABC transporter family. It was found on a multidrug resistance-conferring transposon, Tn6133, which was comprised of Tn554 with a stably integrated 4,787-bp DNA sequence...

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