Article
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality.
DNA repair - 4 Apr 2005
Yonemasu Rie, Minami Mitsuyoshi, Nakatsu Yoshimichi, Takeuchi Masayo, Kuraoka Isao, Matsuda Yoichi, Higashi Yujiro, Kondoh Hisato, Tanaka Kiyoji
Abstract excerpt
The XAB2 protein (XPA-binding protein 2) with 15 tetratricopeptide repeat motifs has been isolated by virtue of its ability to interact with xeroderma pigmentosum group A (XPA) protein in the yeast two-hybrid system. It has been shown that XAB2 interacted with Cockayne syndrome groups A and B (CSA and CSB) proteins and RNA polymerase II, which are known to be involved in transcription-coupled repair (TCR) and...
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