Article
Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Mar 2005
Delaugerre Constance, Roudiere Laurent, Peytavin Gilles, Rouzioux Christine, Viard Jean-Paul, Chaix Marie-Laure
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) resistance profile, K65R, K70E and M184V, on reverse transcriptase gene was associated with the virologic rebound consecutively to the switch of lopinavir/r to tenofovir DF in a stable regimen with nucleoside backbone of abacavir, lamivudine and didanosine. The high selective pressure on the same resistance pathway was probably associated with the loss of antiviral...
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