Article
Characterization of wild-type and deltaF508 cystic fibrosis transmembrane regulator in human respiratory epithelia.
Molecular biology of the cell - 1 May 2005
Kreda Silvia M, Mall Marcus, Mengos April, Rochelle Lori, Yankaskas James, Riordan John R, Boucher Richard C
Abstract excerpt
Previous studies in native tissues have produced conflicting data on the localization and metabolic fate of WT and deltaF508 cystic fibrosis transmembrane regulator (CFTR) in the lung. Combining immunocytochemical and biochemical studies utilizing new high-affinity CFTR mAbs with ion transport assays, we examined both 1) the cell type and region specific expression of CFTR in normal airways and 2) the metabolic...
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