Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland.

doi:10.1038/ng0892-321

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Article

Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland.

Nature genetics - 1 Aug 1992

Kartner N, Augustinas O, Jensen T J, Naismith A L, Riordan J R

Abstract excerpt

Misprocessing and mislocalization of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) has been described for the major CF-causing mutation (delta F508) in heterologous expression systems in vitro. We have generated monoclonal antibodies (mAbs) to CFTR with the aim of localizing the protein and its CF variants in vivo. Of the tissues where CFTR was observed, only the sweat gland is readily...

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Base Sequence
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Genetic Variation
Humans
Intestines
Ion Channels
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Organ Specificity

Pancreas

Recombinant Proteins

Reference Values

Respiratory Physiological Phenomena

Restriction Mapping

Source

Open in PubMed

Identifiers

PMID: 1284548
DOI: 10.1038/ng0892-321

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1284548-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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