Article
The keeshond defect in cardiac conotruncal development is oligogenic.
Human genetics - 1 Apr 2005
Werner Petra, Raducha Michael G, Prociuk Ulana, Ostrander Elaine A, Spielman Richard S, Kirkness Ewen F, Patterson Donald F, Henthorn Paula S
Abstract excerpt
Earlier studies in the keeshond breed of dogs established that isolated conotruncal defects (CTDs) are a group of genetically and embryologically related cardiac malformations, including sub-clinical defects of the conal septum, conal ventricular septal defects, tetralogy of Fallot, and persistent truncus arteriosus. The same spectrum occurs in some human families. In both species, inheritance of non-syndromic...
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