Article
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.
Molecular medicine (Cambridge, Mass.) - 1 Jul 1995
Woods C M, Zhu J, McQueney P A, Bollag D, Lazarides E
Abstract excerpt
BACKGROUND: At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induced by other antineoplastic agents. However, taxol has shown efficacy against drug-refractory cancers, raising the possibility that this pharmacological agent may trigger an alternative apoptotic...
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