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Article

Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway.

Molecular medicine (Cambridge, Mass.) - 1 Jul 1995

Woods C M, Zhu J, McQueney P A, Bollag D, Lazarides E

Abstract excerpt

BACKGROUND: At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induced by other antineoplastic agents. However, taxol has shown efficacy against...

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PMID: 8529117
PMCID: PMC2229961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-8529117-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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