Versatile transgenic multistage effector-gene combinations for <i>Plasmodium falciparum</i> suppression in <i>Anopheles</i>

Abstract excerpt

infection by targeting the parasite with multiple independent endogenous and exogenous effectors at multiple infection stages to potentiate suppression and minimize the probability for development of resistance to develop. We have also addressed the fitness impact of transgene expression on the mosquito. We show that highly potent suppression can be achieved by targeting both pre-oocyst stages by transgenically...

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