Article
Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum.
9 Jul 1996
Abstract excerpt
Genetic studies of the protozoan parasite Plasmodium falciparum have been severely limited by the inability to introduce or modify genes. In this paper we describe a system of stable transfection of P. falciparum using a Toxoplasma gondii dihydrofolate reductase-thymidylate synthase gene, modified to confer resistance to pyrimethamine, as a selectable marker. This gene was placed under the transcriptional control...
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