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Article

A Tetracycline-Repressible Transactivator System to Study Essential Genes in Malaria Parasites

1 Dec 2012

Abstract excerpt

A major obstacle in analyzing gene function in apicomplexan parasites is the absence of a practical regulatable expression system. Here, we identified functional transcriptional activation domains within Apicomplexan AP2 (ApiAP2) family transcription factors. These ApiAP2 transactivation domains were validated in blood-, liver-, and mosquito-stage parasites and used to create a robust conditional expression...

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PMID: 23245327
DOI: 10.1016/j.chom.2012.10.016

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