A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation.

Article

A predictor based on the somatic genomic changes of the BRCA1/BRCA2 breast cancer tumors identifies the non-BRCA1/BRCA2 tumors with BRCA1 promoter hypermethylation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2005

Alvarez Sara, Diaz-Uriarte Ramon, Osorio Ana, Barroso Alicia, Melchor Lorenzo, Paz Maria Fe, Honrado Emiliano, Rodríguez Raquel, Urioste Miguel, Valle Laura, Díez Orland, Cigudosa Juan Cruz, Dopazo Joaquin, Esteller Manel, Benitez Javier

Abstract excerpt

The genetic changes underlying in the development and progression of familial breast cancer are poorly understood. To identify a somatic genetic signature of tumor progression for each familial group, BRCA1, BRCA2, and non-BRCA1/BRCA2 (BRCAX) tumors, by high-resolution comparative genomic hybridization, we have analyzed 77 tumors previously characterized for BRCA1 and BRCA2 germ line mutations. Based on a...

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