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Article

Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis.

Cancer research - 1 Feb 2005

Ma David W L, Finnell Richard H, Davidson Laurie A, Callaway Evelyn S, Spiegelstein Ofer, Piedrahita Jorge A, Salbaum J Michael, Kappen Claudia, Weeks Brad R, James Jill, Bozinov Daniel, Lupton Joanne R, Chapkin Robert S

Abstract excerpt

Low dietary folate intake is associated with an increased risk for colon cancer; however, relevant genetic animal models are lacking. We therefore investigated the effect of targeted ablation of two folate transport genes, folate binding protein 1 (Folbp1) and reduced folate carrier 1 (RFC1), on folate homeostasis to elucidate the molecular mechanisms of folate action on colonocyte cell proliferation, gene...

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Identifiers

PMID: 15705887
PMCID: PMC3938162

Genes

RFC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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