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Article

Comparative genomic hybridization of human breast epithelial cells transformed by estrogen and its metabolites.

International journal of oncology - 1 Mar 2005

Fernandez Sandra V, Russo Irma H, Lareef Mohamed, Balsara Binaifer, Russo Jose

Abstract excerpt

The elevated incidence of breast cancer in women has been associated with prolonged exposure to high levels of estrogens. Our laboratory has demonstrated that treatment of the immortalized human breast epithelial cells MCF-10F with 17beta-estradiol (E2) or its metabolites 4-hydroxy-estradiol (4-OH-E2) and 2-hydroxy-estradiol (2-OH-E2) induces phenotypical changes indicative of neoplastic transformation. The...

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PMID: 15703825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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