Article
Phenotype characterisation using integrated gene transcript, protein and metabolite profiling.
Applied bioinformatics - 1 Jan 2004
Oresic Matej, Clish Clary B, Davidov Eugene J, Verheij Elwin, Vogels Jack, Havekes Louis M, Neumann Eric, Adourian Aram, Naylor Stephen, van der Greef Jan, Plasterer Thomas
Abstract excerpt
Multifactorial diseases present a significant challenge for functional genomics. Owing to their multiple compartmental effects and complex biomolecular activities, such diseases cannot be adequately characterised by changes in single components, nor can pathophysiological changes be understood by observing gene transcripts alone. Instead, a pattern of subtle changes is observed in multifactorial diseases across...
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