Article
A genome scan for all-cause end-stage renal disease in African Americans.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Apr 2005
Freedman Barry I, Bowden Donald W, Rich Stephen S, Valis Christopher J, Sale Michèle M, Hicks Pamela J, Langefeld Carl D
Abstract excerpt
BACKGROUND: In an attempt to map the genes predisposing to the common, complex aetiologies of end-stage renal disease (ESRD), we performed a genome-wide scan in 1023 individuals with chronic kidney disease (946 dialysis dependent and 77 with advanced chronic renal failure) from 483 African American families. METHODS: The study sample comprised 563 ESRD-affected sibling pairs, with nephropathy attributed to...
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