Article
Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1.
Journal of vascular surgery - 1 Jan 2005
Baldwin Zachary K, Chandiwal Amito, Balasubramanian Viji, Pearce Benjamin J, Curi Michael A, Skelly Christopher L, Huang Wendy W, Vosicky James E, Roizman Bernard, Weichselbaum Ralph R, Schwartz Lewis B
Abstract excerpt
OBJECTIVE: Vascular remodeling in response to injury or low shear stress (or both) is characterized by neointimal hyperplasia and luminal contraction. When profound, the response leads to restenosis after percutaneous endovascular intervention as well as to de novo stenosis in vein grafts. It has recently been reported that exposure of vein patches to neurovirulence-attenuated Herpes simplex virus-1 (HSV-1)...
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