Article
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis.
Arthritis and rheumatism - 1 Feb 2005
Kasperkovitz Pia V, Timmer Trieneke C G, Smeets Tom J, Verbeet Nicolette L, Tak Paul P, van Baarsen Lisa G M, Baltus Belinda, Huizinga Tom W J, Pieterman Elsbet, Fero Mike, Firestein Gary S, van der Pouw Kraan Tineke C T M, Verweij Cornelis L
Abstract excerpt
OBJECTIVE: Given the heterogeneity of gene expression patterns and cellular distribution between rheumatoid arthritis (RA) synovial tissues, we sought to determine whether this variability was also reflected at the level of the fibroblast-like synoviocyte (FLS) cultured from RA synovial tissues. METHODS: Gene expression profiles in FLS cultured from synovial tissues obtained from 19 RA patients were analyzed...
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