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Article

Human Ran cysteine 112 oxidation by pervanadate regulates its binding to keratins.

The Journal of biological chemistry - 1 Apr 2005

Tao Guo-Zhong, Zhou Qin, Strnad Pavel, Salemi Michelle R, Lee Young Moo, Omary M Bishr

Abstract excerpt

We used a proteomic approach to identify proteins that associate with keratins 8 or 18 (K8/K18) in a pervanadate-dependent manner. Pervanadate triggers Ran-K8/K18 binding and a gel-migration-shift of Ran from 25 to 27 kDa, which does not occur upon exposure to H2O2 or vanadate or if pervanadate is excluded during cell solubilization. Generation of 27-kDa Ran is not related to hyperphosphorylation, is...

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PMID: 15691838
DOI: 10.1074/jbc.M412505200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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