Article
Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.
The Journal of biological chemistry - 7 Aug 1998
Vecchi M, Rudolph-Owen L A, Brown C L, Dempsey P J, Carpenter G
Abstract excerpt
Enhancement of tyrosine phosphorylation in cells by the application of pervanadate, an extremely potent phosphotyrosine phosphatase inhibitor, provokes the rapid metalloprotease-dependent cleavage of ErbB-4, a transmembrane receptor tyrosine kinase. The pervanadate-induced proteolysis occurs in N...
Topics
- Amphiregulin
- Animals
- Arsenicals
- EGF Family of Proteins
- Enzyme Inhibitors
- ErbB Receptors
- Glycoproteins
- Growth Substances
- Intercellular Signaling Peptides and Proteins
- Metalloendopeptidases
- Mutation
- Peptide Fragments
- Phenylalanine
- Phosphorylation
- Protein Kinase C