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Article

Nfatc1 Coordinates Valve Endocardial Cell Lineage Development Required for Heart Valve Formation

19 May 2011

Abstract excerpt

RATIONALE: Formation of heart valves requires early endocardial to mesenchymal transformation (EMT) to generate valve mesenchyme and subsequent endocardial cell proliferation to elongate valve leaflets. Nfatc1 (nuclear factor of activated T cells, cytoplasmic 1) is highly expressed in valve endocardial cells and is required for normal valve formation, but its role in the fate of valve endocardial cells during...

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Share to Cardiac Fibrosis and Remodeling
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Identifiers

PMID: 21597012
DOI: 10.1161/circresaha.111.245035

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