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Article

Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas.

The Journal of clinical endocrinology and metabolism - 1 May 2005

Porra Valérie, Ferraro-Peyret Carole, Durand Christine, Selmi-Ruby Samia, Giroud Hélène, Berger-Dutrieux Nicole, Decaussin Myriam, Peix Jean-Louis, Bournaud Claire, Orgiazzi Jacques, Borson-Chazot Françoise, Dante Robert, Rousset Bernard

Abstract excerpt

SLC5A8, proposed as a thyroid apical iodide transporter, was recently defined as a Na+-coupled transporter of short-chain fatty acid. To document the expression pattern of SLC5A8 in the thyroid, we analyzed the regulation of its expression in normal human thyrocytes in culture and in tissues with distinct functional activity. To determine whether SLC5A8 expression is altered in all thyroid carcinomas or only in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15687339
DOI: 10.1210/jc.2004-1394

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas.PMID 15687339Read ↗

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The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.Semantic proximity Read ↗

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