Article
Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier.
The American journal of pathology - 1 Feb 2005
Charlier Caroline, Chrétien Fabrice, Baudrimont Marielle, Mordelet Elodie, Lortholary Olivier, Dromer Françoise
Abstract excerpt
Cryptococcus neoformans is a yeast responsible for disseminated meningoencephalitis in patients with cellular immune defects. The major virulence factor is the polysaccharide capsule. We took advantage of a relevant murine model of disseminated meningoencephalitis to study the early events associated with blood-brain barrier (BBB) crossing. Mice were sacrificed at 1, 6, 24, and 48 hours post-intravenous...
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