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Article

Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase1.

Journal of neuroscience research - 15 Mar 2005

Porter Morwenna Y, Turmaine Mark, Mole Sara E

Abstract excerpt

Infantile neuronal ceroid lipofuscinosis (INCL; Batten disease) is a severe neurodegenerative disorder of childhood characterized by the accumulation of autofluorescent storage material in lysosomes. It is caused by mutation of the CLN1/PPT1 gene, which encodes the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1), but the mechanism of disease pathogenesis and substrates for the enzyme are unknown....

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Identifiers

PMID: 15672447
DOI: 10.1002/jnr.20403

Genes

PPT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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