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Article

Palmitoyl-protein thioesterase 1 deficiency in Drosophila melanogaster causes accumulation of abnormal storage material and reduced life span.

Genetics - 1 Apr 2006

Hickey Anthony J, Chotkowski Heather L, Singh Navjot, Ault Jeffrey G, Korey Christopher A, MacDonald Marcy E, Glaser Robert L

Abstract excerpt

Human neuronal ceroid lipofuscinoses (NCLs) are a group of genetic neurodegenerative diseases characterized by progressive death of neurons in the central nervous system (CNS) and accumulation of abnormal lysosomal storage material. Infantile NCL (INCL), the most severe form of NCL, is caused by mutations in the Ppt1 gene, which encodes the lysosomal enzyme palmitoyl-protein thioesterase 1 (Ppt1). We generated...

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Drosophila melanogaster
Microscopy, Electron
Microscopy, Fluorescence
Neurodegenerative Diseases
Neuronal Ceroid-Lipofuscinoses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Interference

Thiolester Hydrolases

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Identifiers

PMID: 16452138
DOI: 10.1534/genetics.105.053306
PMCID: PMC1456391

Genes

NCL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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