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Article

An over-expression system for characterizing Ppt1 function in Drosophila.

BMC neuroscience - 20 Nov 2003

Korey Christopher A, MacDonald Marcy E

Abstract excerpt

BACKGROUND: The infantile onset form of Neuronal Ceroid Lipofuscinoses (INCL) is the earliest and most severe form of NCL, with neurological symptoms that reflect massive neurodegeneration in the CNS and retina. INCL is due to recessively inherited mutations at the CLN1 locus. This locus encodes the evolutionarily conserved enzyme palmitoyl-protein thioesterase 1 (PPT1), indicating an essential role for protein...

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Source

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Identifiers

PMID: 14629778
DOI: 10.1186/1471-2202-4-30
PMCID: PMC280676

Genes

PPT1
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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